Predicting and Retrodicting Fate Patterns in C. elegans Vulval Development using Logic Programming
نویسندگان
چکیده
منابع مشابه
Cell fate patterning during C. elegans vulval development.
Precursor cells of the vulva of the C. elegans hermaphrodite choose between two vulval cell fates (1 degree and 2 degrees) and a non-vulval epidermal fate (3 degrees) in response to three intercellular signals. An inductive signal produced by the anchor cell induces the vulval precursors to assume the 1 degree and 2 degree vulval fates. This inductive signal is an EGF-like growth factor encoded...
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In Caenorhabditis elegans, the fates of the multipotent vulval precursor cells (VPCs) are specified by intercellular signals. The VPCs divide in the third larval stage (L3) of the wild type, producing progeny of determined cell types. In lin-28 mutants, vulva development is similar to wild-type vulva development except that it occurs precociously, in the second larval stage (L2). Consequently, ...
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During vulval development in Caenorhabditis elegans, six precursor cells acquire a spatial pattern of distinct cell fates. This process is guided by a gradient in the soluble factor, LIN-3, and by direct interactions between neighboring cells mediated by the Notch-like receptor, LIN-12. Genetic evidence has revealed that these two extracellular signals are coupled: lateral cell-cell interaction...
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Caenorhabditis elegans vulval development provides an important paradigm for studying the process of cell fate determination and pattern formation during animal development. Although many genes controlling vulval cell fate specification have been identified, how they orchestrate to generate a robust and invariant pattern of cell fates is not yet completely understood. Here, we have developed a ...
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Individual metazoan transcription factors (TFs) regulate distinct sets of genes depending on cell type and developmental or physiological context. The precise mechanisms by which regulatory information from ligands, genomic sequence elements, co-factors, and post-translational modifications are integrated by TFs remain challenging questions. Here, we examine how a single regulatory input, sumoy...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.2129